Canterbury-Bankstown Bulldogs lock David Klemmer will miss the Easter Friday clash with the Rabbitohs with an ankle sprain suffered in last Friday night's victory over the Newcastle Knights.
The Australian representative is hopeful of returning for the Round Eight match-up with the Wests Tigers.
Klemmer's place in the starting line-up will go to Adam Elliott, who has added great energy from the bench in the early rounds.
In further changes, Brett Morris will start at full-back, while Kerrod Holland returns from a shoulder injury to take his place on the wing.
The Bulldogs have won two of the past five Good Friday clashes and aside from last year’s 42-12 demolition of the Rabbitohs, the average margin between the two sides has been 4.25 points.
Since 1999, the two teams have played each other 23 times at ANZ Stadium with the Bulldogs boasting a 15-8 record.
The match starts at 4pm.
NRL Round 7: Bulldogs v Rabbitohs - ANZ Stadium, Friday April 14, 4pm
1 Brett Morris
2 Kerrod Holland
3 Josh Morris
4 Brenko Lee
5 Marcelo Montoya
6 Josh Reynolds
7 Moses Mbye
8 Aiden Tolman
9 Michael Lichaa
10 James Graham
11 Josh Jackson
12 Adam Elliott
13 Greg Eastwood
14 Sam Kasiano
15 Danny Fualalo
16 Francis Tualau
17 Raymond Faitala-Mariner
19 Craig Garvey
20 Matt Frawley
21 Renouf To’omaga
23 Reimis Smith
COACH Des Hasler